Ryder, an executive producer on the film, spent over half the decade trying to make Susanna Kaysen’s memoir of rebellious youth leading to a mandated 1960s stint in a mental hospital. Also on the ward with Ryder as Susanna: psychiatrist Vanessa Redgrave, nurse Whoopi Goldberg, and patients Brittany Murphy, Elisabeth Moss, Clea DuVall, Angela Bettis, Jillian Armenante, and—as an escape-prone sociopath—Oscar-winning Angelina Jolie.